Fast track method for producing monoclonal bi-specific immunoglo

Details Fast track method for producing monoclonal bi-specific immunoglo Fast track method for producing monoclonal bi-specific immunoglo

1988-03-15

1990-01-09

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

43524027, 435948, 435 7021, 436548, 935 89, 935 90, 935 92, 935 93, 935102, C12N 1500, C12N 500, C12N 3353, C12R 191

Patent

active

048928240

ABSTRACT:
An accelerated method for making culturable cells which express bi-specific immunoglobulin employs a three cell fusion procedure which simultaneously fuses a myeloma cell with two B lymphocytes, each of which expresses antibody having a different antigenic specificity.

REFERENCES:
patent: 4714681 (1987-12-01), Reading
Milstein et al., Immunology Today, vol. 5, pp. 299-304.
Corvalan et al., Cancer Immunol. Immunotherap., vol. 24, pp. 127-132, 1987.
Clark et al., J.N.C.I., vol. 79, pp. 1393-1401, 1987.
Suresh et al., Methods in Enzy., vol. 121, pp. 210-228, 1986.
Galpe et al., Methods in Enzy., vol. 73, pp. 3-46, 1981.

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