Fast-melt tablet and method of making same

Details Fast-melt tablet and method of making same Fast-melt tablet and method of making same

1995-11-22

1998-09-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424441, 424465, 514819, A61K 946

Patent

active

058075771

ABSTRACT:
There is provided an improved, fast-melting solid dosage form which readily disintegrates when placed in the mouth. The solid dosage form preferably being a tablet comprising the following primary ingredients whose proportions are calculated as weight percent on the total weight of the tablet: (a) from about 30 to 50 weight percent, of a pharmaceutically acceptable active ingredient component; (b) an effervescent couple consisting of about 3 to 5 weight percent of an effervescence base about 3 to 5 weight percent of an effervescence acid suitable for achieving a gas evolving reaction with the effervescence base upon being contacted with an aqueous solution such as saliva; (c) about 40 to 50 weight percent of a pharmaceutically acceptable starch as a bulking and disintegrating agent; (d) about 3 to 5 weight percent of a tablet lubricant. Additionally, the tablet may comprise flavoring agents. The tablet is formed of granules of a mixture of the active ingredient component, the effervescence base, and the starch, admixed to a powderous blend of the remaining ingredients, subsequently compressed in tablet form. Also provided is a method of making the solid dosage form of the present invention.

REFERENCES:
patent: 3622677 (1971-11-01), Short
patent: 3639168 (1972-02-01), Monti et al.
patent: 3725556 (1973-04-01), Hanssen et al.
patent: 3843778 (1974-10-01), Diamond et al.
patent: 4017598 (1977-04-01), Ohno et al.
patent: 4115553 (1978-09-01), Rubino et al.
patent: 4163777 (1979-08-01), Mitra
patent: 4230693 (1980-10-01), Izzo et al.
patent: 4271142 (1981-06-01), Puglia et al.
patent: 4327076 (1982-04-01), Puglia et al.
patent: 4327077 (1982-04-01), Puglia et al.
patent: 4425332 (1984-01-01), James
patent: 4517179 (1985-05-01), Raghunathan
patent: 4581381 (1986-04-01), Morris et al.
patent: 4605551 (1986-08-01), Buehler et al.
patent: 4609543 (1986-09-01), Morris et al.
patent: 4613497 (1986-09-01), Chavkin
patent: 4684534 (1987-08-01), Valentine
patent: 4996058 (1991-02-01), Sinnreich
patent: 5069910 (1991-12-01), Kovacic et al.
patent: 5219574 (1993-06-01), Wehling et al.
patent: 5225197 (1993-07-01), Bolt et al.
patent: 5254355 (1993-10-01), Smith et al.
patent: 5302396 (1994-04-01), Phadke et al.
patent: 5320848 (1994-06-01), Geyer et al.
patent: 5320852 (1994-06-01), Moest
patent: 5330760 (1994-07-01), Walton
patent: 5348745 (1994-09-01), Daher
patent: 5587179 (1996-12-01), Gergely et al.

Affiliated with

Also associated with

Rating

Fast-melt tablet and method of making same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fast-melt tablet and method of making same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fast-melt tablet and method of making same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-84961