Fast dissolving tablet and its production

Details Fast dissolving tablet and its production Fast dissolving tablet and its production

1995-12-13

1998-02-24

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424493, 424499, 424479, 424489, A61K 920

Patent

active

057209740

ABSTRACT:
A method of producing a fast dissolving tablet comprising compression-molding a composition comprising an active ingredient, a carbohydrate and a barely sufficient amount of water to moisten the surface of particles of said carbohydrate into a tablet form and a fast dissolving tablet obtainable by the method. The active ingredient may for example be a vitamin, a gastrointestinal function conditioning agent or an antipyretic-analgesic-antiinflammatory agent. The carbohydrate includes sugar, starch sugars, lactose, honey, sugar alcohols and tetroses. The amount of water to be added is about 0.3 to 10% by weight. The above fast dissolving tablet has a porous structure with excellent disintegratability and solubility as well as adequate strength.

REFERENCES:
patent: 2926121 (1960-02-01), Hobbs et al.
patent: 4414198 (1983-11-01), Michaelson
patent: 4946684 (1990-08-01), Blank et al.
patent: 5082667 (1992-01-01), Van Scoik
patent: 5085869 (1992-02-01), Olthoff
patent: 5112616 (1992-05-01), McCarty
patent: 5215756 (1993-06-01), Gole et al.
patent: 5456920 (1995-10-01), Matoba et al.
Zydis, Manufacturing Chemist, 1990, pp. 36-37.

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