Fas peptide mimetics and uses thereof

Details Fas peptide mimetics and uses thereof Fas peptide mimetics and uses thereof

2007-10-30

2007-10-30

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S317000

Reexamination Certificate

active

10445399

ABSTRACT:
Exocyclic peptide mimetics that disable Fas were developed. A three dimensional model of the Fas receptor-ligand complex was constructed and structurally predicted regions of the receptor that were relevant to binding ligand were used to create constrained peptide mimetics. Exocyclic anti-Fas peptide mimetics were identified that block Fas receptor-ligand interactions, and modulate Fas biological activity both in vitro and in vivo. The mimetics are useful, e.g., for treating Fas-related pathologies.

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Hasegawa, Akihiro et al. “FAS-Disabling Small Exocyclic Peptide Mimetics Limit Apoptosis by an Unexpected Mechanism.” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, No. 17, Apr. 27, 2004; 6599-6604, XP002360129; ISSN: 0027-8424.

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