FAS ligand derived polypeptides

Details FAS ligand derived polypeptides FAS ligand derived polypeptides

2004-06-07

2009-11-24

Allen, Marianne P (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S006120, C536S023500

Reexamination Certificate

active

07622554

ABSTRACT:
This invention provides a polypeptide useful in the field of medicines, a DNA which encodes the novel polypeptide, a recombinant DNA molecule which contains the DNA, a transformant transformed with the DNA or the recombinant DNA molecule, a process for the purification of the polypeptide, a process for the production of the polypeptide, an antibody which recognizes the polypeptide, an oligonucleotide complementary to the DNA and a screening method. Particularly this invention provides a polypeptide, which is Fas ligand or a fragment thereof. This polypeptide can be used as an effective ingredient of a medicament for regulating the apoptosis in a living body. This polypeptide is obtained by identifying a DNA fragment, which encodes the polypeptide, transforming a desired host with a recombinant DNA molecule, which contains the DNA fragment, and purifying the polypeptide produced by the resulting transformant. This polypeptide has a cytoplasmic domain, a transmembrane domain and extracellular domain and takes part in apoptosis.

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