Fas ligand compositions for treatment of proliferative disorders

Details Fas ligand compositions for treatment of proliferative disorders Fas ligand compositions for treatment of proliferative disorders

1997-03-04

1999-01-12

Elliott, George C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 4351721, 4353201, 435 691, 435375, 435377, A61K 4800, C12N 1511

Patent

active

058589902

ABSTRACT:
A method for treating vascular injury, particularly vascular injury resulting from restenosis following angioplasty, and vascular remodeling is provided. The method involves administering to subjects in need of such treatment an effective amount of a Fas ligand molecule.

REFERENCES:
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patent: 5563039 (1996-10-01), Goeddel et al.
Tanaka, M., et al., "Expression of the Functional Soluble Form of Human Fas Ligand in Activated Lymphocytes", The EMBO Journal, (1995), 14:6:1129-1135.
Han, D. K., et al., "Evidence for Escape of Apoptosis by Loss of Fas in Atherosclerotic Plaque Smooth Muscle Cells", Supplement 1-Circulation, (1996) 94:6, Abstract 2311.
Alvarez, R.J., et al., "Induction of Fas in Pertussis Toxin Treated Endothelial Cells: Implications for . . . Apoptosis", Supplement 1-Circulation, (1996) 94:6, Abstract 0590.
Bishopp Frances, "Ceres' Research Explores Use of Fas Ligand in Immune System Suppression, Tumors", Bioworld Today, (1996), 7:252:1.
Orkin et al "Report and Reccomendations of the Panel to Asses the NIH Investment in Research on Gene Therapy", Dec. 7, 1995.
Takahashi, T. Mol Human Fas Ligand: Gene Structure, Chromosomal Location and Species Specificity: International Immunology vol. 6(10): 1567-1574, 1994.
Mita, E. et al "Role of Fas Ligand in Apoptosis Induced by Hepatitis C Virus Infection." Biochemical and Biophysical Research Communications vol. 204(2):468-474, Oct. 28, 1994.

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