Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...
Patent
1995-03-27
1997-05-27
Zitomer, Stephanie W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Hormone or other secreted growth regulatory factor,...
435 71, 435 72, 435 79, 4241851, 4241921, 5303873, 5303879, A61K 3900, G01N 3353, C07K 1600
Patent
active
056329946
ABSTRACT:
The present invention provides mammalian protein tyrosine phosphatases, human PTP-BAS type 4, human PTP-BAS type 5a and mouse PTP-BAS type 5b, each of which is a Fas-associated protein (FAP), nucleic acid molecules encoding a PTP-BAS type 4 or a PTP-BAS type 5 and antibodies specific for a PTP-BAS type 4 or for a PTP-BAS type 5. The invention also provides methods for identifying FAP's, which can associate with Fas and can modulate apoptosis. The invention also provides screening assays for identifying an agent that can effectively alter the association of a FAP with Fas and, therefore, can increase or decrease the level of apoptosis in a cell. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a PTP-BAS or fragment of a PTP-BAS or an antisense nucleotide sequence, which is complementary to a portion of a nucleic acid molecule encoding a PTP-BAS. The invention also provides a method of using a reagent that can specifically bind to a FAP to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell. The invention also provides methods of modulating apoptosis in a cell by contacting the cell with an agent that effectively alters the association of a FAP and Fas in a cell or alters the activity of a FAP in a cell.
REFERENCES:
International Search Report, PCT/US95/07583, Filed: Jun. 14, 1995.
Sato, Takaaki et al., "FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas." Science 268:411-415 (1995).
Itoh, Naoto et al., "The Polypeptide Encoded by the CDNA for Human Cell Surface Antigen Fas Can Mediate Apoptosis." Cell 66:233-243 (1991).
Maekewa et al. FEBS LETT. 337: 200-206.
Reed John C.
Sato Takaaki
La Jolla Cancer Research Foundation
Rees Dianne
Zitomer Stephanie W.
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