Fas antigen derivative

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C536S001001, C536S018700, C536S022100, C536S023100, C536S023400, C530S300000, C530S350000, C530S385000, C530S386000, C530S387100, C435S069100, C435S320100, C435S325000

Reexamination Certificate

active

06953847

ABSTRACT:
This invention provides a novel Fas antigen derivative which comprises at least a part or entire portion of Fas antigen extracellular region polypeptide in which at least one amino acid residue is deleted from a group of amino acid residues starting from the N-terminal amino acid residue of the Fas antigen polypeptide to a cysteine residue most close to the N-terminal side (excluding said cysteine residue), as well as a DNA fragment which encodes said Fas antigen derivative, a recombinant DNA molecule which contains said DNA sequence, a transformant in which said recombinant DNA molecule is introduced, a method for the production of said Fas antigen derivative, a medicament which contains said novel Fas antigen derivative as the active ingredient and a method for the improvement of activities and functions of Fas antigen and the like.

REFERENCES:
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Kimura et al. A variant mRNA species encoding a truncated form of fas antigen in the rat liver. Biochemical and Biophysical Research Communication, 198(2): 666-674, Jan. 28, 1994.
Adachi et al. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antgen gene of Ipr mice. Proc. Natl. Sci. USA 90: 1756-1760, Mar. 1993.
Amino acid database, Alignment between Applicants' Seq Id No: 15 and sequences from Biochem. Biophys. Res. Commun. 1994 and Proc. Natl. Acad. Sci. USA, 1993.
Tanaka M. et al., “Expression of the functional soluble form of human Fas ligand in activated lymphocytes”; EMBO Journal, vol. 14, No. 6, pp. 1129-1135 (1995).
Tanaka, M. et al., “Fas ligand in human serum”, Nature Medicine, vol. 2, pp. 317-322 (1996).
Suda, T. et al., “Purification and Characterization of the Fas-ligand that Induces Apoptosis”; J. Exp. Med.; vol. 179, No. 3, pp. 873-879 (1994).
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Ed. Nikkei Baioteku (Nikkei BP Sha) “Nikkei Baio Saishin-Yogo Jiten '91 (in Japanese” p. 550 (1991).

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