Fas antagonists and uses thereof

Details Fas antagonists and uses thereof Fas antagonists and uses thereof

1995-04-26

1998-11-03

Loring, Susan A.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241431, 4241531, 4241541, 4241551, 4241561, 5303882, 53038822, 53038823, 53038824, 435332, A16K 39395, A16K 3512, C07K 1618, C12N 512

Patent

active

058304690

ABSTRACT:
The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand-mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.

REFERENCES:
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Katsikis, et al., "HIV type 1 Tat protein enhances activation-but not Fas (CD95)-induced peripheral blood T cell apoptosis in healthy individuals", International Immunology 9: 835-841, 1997.
Katsikis, et al., "Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals", International Immunology 8: 1311-1317, 1996.
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