Farnesyltransferase inhibitors

Details Farnesyltransferase inhibitors Farnesyltransferase inhibitors

2008-01-29

2008-01-29

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S341000

Reexamination Certificate

active

11459745

ABSTRACT:
Substituted imidazoles and thiazoles having the formulaare useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

REFERENCES:
patent: 5245061 (1993-09-01), Singh
patent: 5854264 (1998-12-01), Anthony et al.
patent: 5854265 (1998-12-01), Anthony
patent: 5859035 (1999-01-01), Anthony et al.
patent: 5872136 (1999-02-01), Anthony et al.
patent: 5874452 (1999-02-01), Anthony
patent: 5880140 (1999-03-01), Anthony
patent: 5883105 (1999-03-01), Anthony
patent: 5939557 (1999-08-01), Anthony et al.
patent: 6080870 (2000-06-01), Anthony et al.
patent: 6143766 (2000-11-01), Kaltenbronn et al.
patent: 9736875 (1997-10-01), None
patent: 9736876 (1997-10-01), None
patent: 9736881 (1997-10-01), None
patent: 9736897 (1997-10-01), None
patent: 9736901 (1997-10-01), None
patent: 9917777 (1999-04-01), None
patent: 9918096 (1999-04-01), None
patent: 9920609 (1999-04-01), None
patent: 9927928 (1999-06-01), None
patent: 9927929 (1999-06-01), None
patent: 9927933 (1999-06-01), None
patent: 9928313 (1999-06-01), None
patent: 9928314 (1999-06-01), None
patent: 0012498 (2000-03-01), None
Goldstein, J.L. et al., “Nonfamesylated Tetrapeptide Inhibitors of Protein Famesyltransferase, ” Journal of Biological Chemistry 266(24):15575-15578 (1991).
IUPAC, IUPAC “Commission on Nomenclature of Organic Chemistry, Rules for the Nomenclature of Organic Chemistry, ” 45:13-30 (1976).
Moores, S.L. et al., “Sequence Dependence of Protein Isoprenylation, ” Journal of Biological Chemistry 266 (22):14603-14610 (1991).
Reiss, Y. et al., “Inhibition of Purified p21ras Farnesyl: Protein Transferase by Cys-AAX Tetrapeptides, ” Cell 62:81-88 (1990).
Vogt, A. et al., “Non-Peptide Mimetic of Ras-CAAX: Selective Inhibition of Farnesyltransferase and Ras Processing, ” Journal of Biological Chemistry 270(2):660-664 (1995).

Affiliated with

Also associated with

Rating

Farnesyltransferase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Farnesyltransferase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Farnesyltransferase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3921172