Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-08-19
1999-07-20
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142228, A61K 31495, A61K 3154
Patent
active
059256419
ABSTRACT:
The present invention relates to a farnesyltransferase inhibitor and an antitumor agent comprising, as an active ingredient, a piperazinedione derivative represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent lower alkyl, lower alkoxyalkyl, substituted or unsubstituted aryl, or aralkyl; R.sup.3 and R.sup.4 independently represent mercapto, lower alkanoylthio, aroylthio, lower alkoxycarbonylthio, or aryloxycarbonylthio, or alternatively R.sup.3 and R.sup.4 are combined together to form disulfide; and R.sup.5 and R.sup.6 independently represent hydrogen, lower alkyl, lower alkoxyalkyl, hydroxyalkyl, lower alkanoyloxyalkyl, aroyloxyalkyl, aralkyloxyalkyl, or aralkyl.
REFERENCES:
patent: 3562253 (1971-02-01), Trown
patent: 3883561 (1975-05-01), Michel et al.
patent: 4007190 (1977-02-01), Shen et al.
Akasaka Kazuhito
Kanda Yutaka
Mizukami Tamio
Nakano Hirofumi
Saitoh Yutaka
Goldberg Jerome D.
Kyowa Hakko Kogyo Co. Ltd.
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