Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1992-12-23
1994-03-22
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
546322, 560138, 514356, A61K 31215, C07C 69017
Patent
active
052965082
ABSTRACT:
The invention relates to novel farnesylated tetrahydro-naphthalenols, that inhibit HMGR activity which results in a decrease in serum total cholesterol, a decrease in LDL cholesterol levels, and inhibition of LDL oxidation. The farnesylated tetrahydro-naphthalenols of the present invention are thus useful for cholesterol/lipid lowering in cases of hypercholesterolemia, hyperlipidemia, and atherosclerosis.
REFERENCES:
patent: 4680310 (1987-07-01), Hengartner et al.
Almaula Prabodh I.
Bristol--Myers Squibb Company
Cintins Marianne M.
Peabody John
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