Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1979-11-21
1981-09-15
Sutto, Anton H.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
26032645, 260404, 544399, 546248, 424267, 424274, 424250, A61K 3123, C09F 508
Patent
active
042897866
ABSTRACT:
Novel farnesylacetic acid ester derivatives containing an amine nitrogen in the alcohol residue thereof and represented by the following general formula exhibit high levels of antiulcerogenic activity and very low levels of toxicity: ##STR1## wherein A is an alkylene radical containing at least 2 carbon atoms; R.sup.1 is H, alkyl, cycloalkyl, aryl, aralkyl or alkenyl; R.sup.2 and R.sup.3 are independently H, alkyl, aryl, aralkyl or alkenyl or one of R.sup.2 and R.sup.3 forms, together with A, a piperidine, pyrrolidine, tetrahydropyrimidine or piperazine ring which contains the nitrogen atom lying therebetween or R.sup.2 and R.sup.3 combine to form, together with the adjacent nitrogen atom, a piperazine ring; provided that the total number of carbon atoms contained in A, R.sup.1, R.sup.2 and R.sup.3 is at least 5.
REFERENCES:
patent: 3154570 (1964-10-01), Adami et al.
patent: 3928403 (1975-12-01), Fujita et al.
patent: 4025539 (1977-05-01), Fujita et al.
Crescenzi et al., "Il Farmaco, Ed., SC", vol. 19, (1964), pp. 757-764.
Minoli et al., "Il Farmaco", vol. 28, (1973), pp. 534-544.
Fujita Yoshiji
Ninagawa Yoichi
Okabe Susumu
Omura Yoshiaki
Kramer Barry
Kuraray Co. Ltd.
Sutto Anton H.
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