Farnesyl transferase inhibiting quinoline and quinazoline...

Details Farnesyl transferase inhibiting quinoline and quinazoline... Farnesyl transferase inhibiting quinoline and quinazoline...

2006-05-30

2006-05-30

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S314000, C514S311000, C546S159000, C546S169000, C546S173000, C546S168000, C546S170000

Reexamination Certificate

active

07053105

ABSTRACT:
This invention comprises the novel compounds of formula (I) wherein r, s, t, Y1—Y2, R1, R2, R3, R4, R5and R7have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.

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Kohl et al., “Selective Inhibition of ras-Dependent Transformation by a Farnesyttransferase Inhibitor,”Science, 1993, pp. 1934-1937, vol. 260, No. 5116.
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