Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-27
2006-06-27
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S157000
Reexamination Certificate
active
07067531
ABSTRACT:
This invention comprises the novel compounds of formula (I)wherein r, t, Y1—Y2, R1, R2, R3, R4, R5, R6and R7have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
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Kohl et al., “Selective Inhibition of ras-Dependent Transformation by a Famesyltransferase Inhibitor.”Science, 1993, pp. 1934-1937, vol. 260, No. 5116.
Rak et al., “Mutant ras Oncogenes Upregulate VEGF/VPF Expression: Implications for Induction and Inhibition of Tumor Angiogenesis.”Cancer Research, 1995, pp. 4575-4580, vol. 55, No. 20.
Angibaud Patrick Rene
Mevellec Laurence Anne
Venet Marc Gaston
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