Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus acids or salts thereof
Patent
1993-06-18
1994-11-08
Cintins, Marianne M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus acids or salts thereof
562 15, 562 24, 562567, 562579, 558202, 558207, 558170, 435184, A01N 4710, C07C22900
Patent
active
053629060
ABSTRACT:
The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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Anthony Neville J.
Lee Ta-jyh
Smith Robert L.
Stokker Gerald E.
Cintins Marianne M.
Daniel Mark R.
DiPrima Joseph F.
MacMillan Keith
Merck & Co. , Inc.
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