Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1991-09-27
1994-03-29
Dees, Joseel G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
554155, 560183, 562579, 562289, 562555, 562 15, 562 23, 562 24, 558170, C07C 5702, C07F 902, A01N 2700
Patent
active
052986551
ABSTRACT:
The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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Anthony Neville J.
Lee Ta-jyh
Smith Robert L.
Stokker Gerald E.
Daniel Mark R.
Dees Joseel G.
DiPrima Joseph F.
MacMillan Keith
Merck & Co. , Inc.
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