Farnesyl: protein transferase inhibitors as anticancer agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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514129, 558177, 558178, 562 23, 562 24, A61K 3166, C07F 938, C07F 940

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054631815

ABSTRACT:
The present invention relates to certain inhibitors of farnesyl:protein transferase which are useful as antineoplastic agents.

REFERENCES:
patent: 4541858 (1985-09-01), Pfister et al.
Halazy, S. et al. J. Chem. Soc. Chem. Comm. 1992, (101, 743-745).
Burton, D. J. et al. Chem. Lett. 1982, (5), 755-758.
Obayashi, M. et al. Tetrahedron Lett 1982, 23(22), 2323-2326.
Chem. Abstr. 1985, 102(13), 113737; Pfister, T. et al. DE 3,313,070; 18 Oct. 1984.
Chem. Abstr. 1987, 107 (23), 217736; Moskva, V. V. et al. Zh. Obshch. Khim. 1987, 57(1), 234-5.
Schafer, et al., Science 245: 379-385 (Jul. 28, 1989).
Bos, Cancer Research 49:4682-4689 (Sep. 1, 1989).
Pompliano, et al., Biochemistry 31:3800-3807 (1992).
Maltese, FASEB Journal 4:3319-3328 (Dec. 1990).
Casey, et al., Proc. Natl. Acad. Sci. USA 86:8323-8327 (Nov. 1989).
Goldstein, et al., J of Biological Chemistry 266(24): 15575-15578 (Aug. 25, 1991).
Cox, et al., Molecular and Cellular Biology 12(6):2606-2615 (Oct. 1992).
Biller, et al., Tetrahedron 46(19):6645-6658 (1990).

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