Farnesyl derivatives and pharmaceutical compositions...

Details Farnesyl derivatives and pharmaceutical compositions... Farnesyl derivatives and pharmaceutical compositions...

2007-06-05

2007-06-05

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S622000, C514S619000, C514S918000, C514S602000, C564S087000, C564S086000, C564S085000, C564S166000, C564S016000, C564S162000, C564S163000, C564S176000, C564S165000, C562S473000, C562S432000, C562S047000, C562S458000, C558S423000, C558S418000, C558S413000

Reissue Patent

active

11093255

ABSTRACT:
Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula:whereinR1represents farnesyl, geranyl or geranyl-geranyl;Z represents C—R6or N;R2represents H, CN, the groups COOR7, SO3R7, CONR7R8and SO2NR7R7, wherein R7and R8are each independently hydrogen, alkyl, alkenyl, and the groups COOM and SO3M, wherein M is a cation;R3, R4, R5and R6are each independently hydrogen, carboxyl, alkyl, alkenyl, aminoalkyl, nitroalkyl, nitro, halo, amino, mono- or di-alkylamino, mercapto, mercaptoalkyl, azido, or thiocyanato;X represents O, S, SO, SO2, NH or Se; and the quaternary ammonium salts and N-oxides of the compounds of formula I wherein Z is N.

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