Farnesyl compounds as cholesterol lowering agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514722, 514739, 560205, 568687, A61K 3123, A61K 3108, A61K 31045

Patent

active

054750296

ABSTRACT:
Farnesyl derivatives, particularly farnesyl acetate, are used to lower the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity in cells, thereby reducing cholesterol biosynthesis. The compounds may be administered to hypercholesterolemia patients to reduce the overall level of serum cholesterol, either alone or in conjunction with other drugs conventionally used for the treatment of hypercholesterolemia.

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Parker et al., "Tocotrienols Regulate Cholesterol Production in Mammalian Cells by Posttranscriptional Suppression of 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase", The Jounal of Biological Chemistry, 268(15):11230-11238 (1993).
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