Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1993-07-08
1995-12-12
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514722, 514739, 560205, 568687, A61K 3123, A61K 3108, A61K 31045
Patent
active
054750296
ABSTRACT:
Farnesyl derivatives, particularly farnesyl acetate, are used to lower the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity in cells, thereby reducing cholesterol biosynthesis. The compounds may be administered to hypercholesterolemia patients to reduce the overall level of serum cholesterol, either alone or in conjunction with other drugs conventionally used for the treatment of hypercholesterolemia.
REFERENCES:
patent: Re33885 (1992-04-01), Mattson
patent: 4434179 (1984-02-01), Kobayashi et al.
patent: 4871720 (1989-10-01), Jaeggi
patent: 5025003 (1991-06-01), Biller
patent: 5026554 (1991-06-01), Bartizal et al.
CA 106:196638, Toshihiro et al, Isoprenyl Benzoates (1985).
Datey et al, "Ethyl Linoleate as an Antiatherogenic Agent", Angiology, Oct. 1966, 17(10) pp. 732-737.
Spady et al, "Regulation of Plasma LDL-Cholesterol Levels by Dietary Cholesterol and Fatty Acids", Annul. Rev. Nutr., 1993, 13:355-381.
Biller et al., "Isoprenoid (Phosphinylmethyl)phosphonates as Inhibitors of Squalene Synthetase", Journal of Medicinal Chemistry, 31(10):1869-1871 (1988).
Parker et al., "Tocotrienols Regulate Cholesterol Production in Mammalian Cells by Posttranscriptional Suppression of 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase", The Jounal of Biological Chemistry, 268(15):11230-11238 (1993).
Pearce et al., "Hypocholesterolemic Activity of Synthetic and Natural Tocotrienols", J. Med. Chem., 35:3595-3606 (1992).
Sugiyama et al., "Isolation of Plasma Cholesterol-Lowering Components from Ningyotake (Polyporus confluens) Mushroom", J. Nutr. Sci. Vitaminol., 38:335-342 (1992).
Bradfute David L.
Simoni Robert D.
Lambkin Deborah
Robinson Allen J.
Rowland Bertram I.
Sherwood Pamela J.
The Board of Trustees of the Leland Stanford Junior University
LandOfFree
Farnesyl compounds as cholesterol lowering agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Farnesyl compounds as cholesterol lowering agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Farnesyl compounds as cholesterol lowering agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1360197