Farnesene derivatives, mucosal stabilizing compositions and meth

Details Farnesene derivatives, mucosal stabilizing compositions and meth Farnesene derivatives, mucosal stabilizing compositions and meth

1983-06-27

1985-05-28

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514627, 260404, 2604109N, 560157, C07C125065, C07C103133, A61K 3127, A61K 3123

Patent

active

045200297

ABSTRACT:
Some new compounds, farnesyl farnesyl carboxylate, N-farnesyl farnesyl carboxamide and N-farnesyl farnesyl carbamate are disclosed, which are novel mucosal stabilizing agents showing anti-inflammative and anti-ulcerative activities. These new compounds are prepared by the reaction of farnesyl carboxylic acid with farnesol or farnesylamine.

REFERENCES:
patent: 2187694 (1940-01-01), Slagh
patent: 3105089 (1963-09-01), Kupchan
patent: 3584015 (1971-06-01), Lee
patent: 3746748 (1973-07-01), Ratusky
Martindale, "The Extra Pharmacopoeia," 28th Ed., p. 80.
Cardani, J.M.C., 6, pp. 457-458, (1963).
Adami, Med. Exp., 7, pp. 171-176, (1962).
Adami, Experientia, 18, p. 461, (1962).
Shioiri, J.A.C.S., 94, pp. 6203-6205, (1972).
Allinger, "Organic Chemistry," pp. 528-530, (1971).

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