Famotidine intermediates and their preparation

Details Famotidine intermediates and their preparation Famotidine intermediates and their preparation

1990-07-06

1991-11-26

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonic acids or salts thereof

562 86, 562114, 562602, 562605, 564 79, C07C30700, C07C 5310, C07C30904, C07C30930

Patent

active

050684051

ABSTRACT:
Halogenated N-sulfamyl propionamidine addition salts corresponding to the formula ##STR1## are provided, in which X represents halogen and A represents an acid selected from sulfuric acid, nitric acid, benzenesulfonic acid; toluenesulfonic acid; 2,4,5-trichlorobenzenesulfonic acid; trichloroacetic acid; trifluoroacetic acid or methanesulfonic acid. They are useful as intermediates in the preparation of famotidine. They are prepared by reacting a halogenated propionitrile with the respective acid.

REFERENCES:
patent: 3121084 (1964-02-01), Winberg
patent: 4675134 (1987-06-01), Miura et al.
patent: 4731479 (1988-03-01), Bod et al.

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