Family of mammalian potassium channels, their cloning and their

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 435325, 536 231, C12P 2106, C12N 1500, C12N 1563, C07H 2102

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active

060134704

ABSTRACT:
The present invention relates to the cloning of a member of a new potassium channel named TWIK-1. More specifically, it relates to an isolated and purified nucleic acid molecule coding for a protein constituting a potassium channel exhibiting the properties and structure of the TWIK-1 type channel, as well as the protein coded by this nucleic acid molecule.
The invention also relates to the use of this nucleic acid molecule to transform cells, and the use of these cells expressing the potassium channels exhibiting the properties and structure of the TWIK-1 type channel for the screening of drugs.

REFERENCES:
Ketchum et al. Nature. 376, 690-694, Aug. 1995.
Lesage et al. Genomics 34, 153-155, 1996.

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