Family of linear antimicrobial peptides from hagfish intestine

Details Family of linear antimicrobial peptides from hagfish intestine Family of linear antimicrobial peptides from hagfish intestine

1996-06-18

1998-03-31

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

514 12, C07K 700

Patent

active

057340153

ABSTRACT:
A new family of linear antimicrobial peptide from hagfish intestine is described. This invention relates to proteins with antimicrobial properties isolated from hagfish intestine and their corresponding chemical sequences. The antibiotics obtained include, but are not limited to, peptides having a sequence selected from the group consisting of: ##STR1##

REFERENCES:
patent: 5254537 (1993-10-01), Zasloff
Peter J. Hanley, et al., Proc. Natl. Acad. Sci. USA, Immunology, "Hagfish Humoral Defense Protein Exhibits Structural and Functional Homology with Mammalian Complement Components," vol. 89, pp. 7910-7914, Sep. 1992.
Judith Varner, et al., Proc. Natl. Acad. Sci. USA, Immunology, "A Serum Heterodimer from Hagfish (Eptatretus Stoutii) Exhibits Structural Similarity and Partial Sequence Identity with Immunoglobulin," vol. 88, pp. 1746-1750, Mar. 1991.
Allen et al., "Synthesis of 5-and 7-Bromotryptophan and of 24)-tetracosapeptide, a Highly Potent Corticortrophin Analogue," J. Chem. Soc., Perkin Transactions I, pp. 1928-1932 (1980).
Reid et al., "Immunohistochemical Localisation of Bioactive Peptides and Amines Associated with the Chromaffin Tissue of Five Species of Fish," Cell & Tissue Res., 230:499-512 (1995); (Biological Abstracts, vol. 5, Abst. No. 63640 (1995)).
Shinnar et al., "New Family of Linear Antimicrobial Peptides from Hagfish Intestine Contains Bromo-tryptophan as Novel Amino Acid," Peptides Chemistry, Structure and Biology, Kaumaya et al., eds., Mayflower Scientific Ltd., pp. 189-191 (1996).
Shinnar et al., "New Family of Linear Antimicrobial Peptides from Hagfish Intestine Contains Bromo-tryptophan as Novel Amino Acid," Abstract Form--Fourteenth American Peptide Symposium, Columbus, Ohio Jun. 18-23, 1995.
Shinnar et al., "New Family of Linear Antimicrobial Peptides from Hagfish Intestine Contains Bromo-tryptophan as Novel Amino Acid," Program of Sessions for the Fourteenth American Peptide Symposium, Columbus, Ohio Jun. 18-23, 1995.

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