Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1993-02-16
1995-12-05
Parr, Margaret
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
435 691, 4351723, 43524027, 935 12, 935 15, 5303877, 4241381, C07K 1628, A61K 39395
Patent
active
054726930
ABSTRACT:
The present invention discloses novel chimeric monoclonal antibodies directed against human carcinoembryonic antigen, having antigen-specific variable regions. DNA constructs for the light and heavy chain variable regions comprising the novel antibodies of the invention are also disclosed. Eukaryotic host cells capable of expression of the chimeric antibodies and comprising the novel chimeric antibody-encoding DNA constructs are also described.
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Gourlie Brian B.
Kaplan Donald A.
Mezes Peter S.
Rixon Mark W.
Schlom Jeffrey
Culmer D.
Kimble K. L.
National Institutes of Health
Nisbet T. Michael
Parr Margaret
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