Failure of passive transfer immune serum and method of making sa

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303891, 530414, 530829, 530830, 530861, 378 66, 4241301, 4241841, C07K 1600, C07K 134, A61K 39395

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active

055480667

ABSTRACT:
An immunological serum and method of making same. The serum essentially consists of purified and concentrated materials, sometimes known as transfer factor, and immunoglobulins, expressed from the clotted blood of a donor group having known immunity. To produce the serum, a group of donors is chosen which includes known immunity, preferably to a wide variety of ailments. Blood is drawn from the donor group and allowed to clot. Thereafter, the blood is filtered to remove all cellular material, producing raw serum. This raw serum is then concentrated by removal of water. The concentrated serum is then sterilized, but not denatured, by freezing and gamma irradiation.

REFERENCES:
patent: 2386725 (1945-10-01), Shean
patent: 3743480 (1973-07-01), Falk
patent: 4349539 (1982-09-01), Wampler
patent: 4665159 (1987-05-01), Dobkin
patent: 5362442 (1994-11-01), Kent
Mangold et al. "Passive Transfer w/ Serum & IgG Antibodies of Irradiated Cercaria-Induced Resistance Against Schistosoma Mansoni In Mice".
J. Immunol. 136(7): 2644-2648 1986.

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