Fadd-like anti-apoptotic molecules, flame-1 and flame-2, methods

Details Fadd-like anti-apoptotic molecules, flame-1 and flame-2, methods Fadd-like anti-apoptotic molecules, flame-1 and flame-2, methods

1998-06-30

2000-05-16

Eyler, Yvonne

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530324, A01N 3718, A61K 3800, C07K 500, C07K 700, C07K 1600

Patent

active

060637609

ABSTRACT:
Two FADD-like anti-apoptotic proteins FLAME-1 and FLAME-2 that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anti-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.

REFERENCES:
patent: 4736866 (1988-04-01), Leder et al.
patent: 4873191 (1989-10-01), Wagner et al.
patent: 5108921 (1992-04-01), Denny et al.
Ahmad, et al., "CRADD, a Novel Human Apoptotic Adaptor Molecule for Caspase-2, and FasL/ Tumor Necrosis Factor Receptor-interacting Protein RIP.sup.1 ", Cancer Res., 1997, 57, 615-619.
Alnemri, et al., "Human ICE/CED-3 Protease Nomenclature", Cell, 1996, 87, 171.
Alnemri, "Mammalian Cell Death Proteases: A Family of Highly Conserved Aspartate Specific Cysteine Proteases", J. Cell. Biol., 1997, 64, 33-42.
Arad, et al., "Use of reconstituted Sendai virus envelopes for fusion-mediated microinjection of double-stranded RNA: inhibition of protein synthesis in interferon-treated cells", Biochim. Biophys. Acta, 1986, 859, 88-94.
Bertin, et al., "Apoptotic Suppression by Baculovirus P35 Involves Cleavage by and Inhibition of a Virus-Induced CED-3/ICE-Like Protease", J. Virol., 1996, 70, 6251-6259.
Boldin, et al., "Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor-Induced Cell Death", Cell, 1996, 85, 803-815.
Bullrich, et al., "Chromosomal Mapping of Members of the cdc2 Family of Protein Kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk Inhibitor, p27.sup.Kip1, to Regions Involved in Human Cancer", Cancer Research, 1995, 55, 1199-1205.
Capecchi, M.R., "Altering the Genome by Homologous Recombination", Science, 1989, 244, 1288-1292.
Fernandes-Alnemri, et al., "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine proteases containing two FADD-like domains", Proc. Natl. Acad. Sci. USA, 1996, 93, 7464-7469.
Fernandes-Alnemri, et al., "CPP32, a Novel Human Apoptotic Protein with Homology to Caenorhabditis elegans Cell Death Protein Ced-3 and Mammalian Interleukin-1.beta.-converting Enzyme", J. Biol. Chem., 1994, 269, 30761-30764.
Henkart, "ICE Family Proteases: Mediator of All Apoptotic Cell Death", Immunity, 1996, 4, 195-201.
Li, et al., "Mice Deficient in IL-1.beta.-Converting Enzyme Are Defective in Production of Mature IL-1.beta. and Resistant to Endotoxic Shock", Cell, 1995, 80, 401-411.
Lu, et al., "UV irradiation-induced apoptosis leads to activation of a 36-kDa myelin basic protein kinase in HL-60 cells", Proc. Natl. Acad. Sci. USA, 1996, 93, 8977-8982.
Muzio, et al., "FLICE, A Novel FADD-Homologous ICE/CED-3-like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex", Cell, 1996, 85, 817-827.
Nagata, S., "Apoptosis by Death Factor", Cell, 1997, 88, 355-365.
Nagata, S., "Fas-Mediated Apoptosis", Adv. Exp. Med. Biol., 1996, 406, 119-124.
Nagata, S. And Golstein, P., "The Fas Death Factor", Science, 1995, 267, 1449-1456.
Nagata, S., "Fas and Fas Ligand: A Death Factor and Its Receptor", Adv. Immunol., 1994, 57, 129-144.
Rosette, C. And Karin, M., "Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors", Science, 1996, 274, 1194-1197.
Srinivasula, et al., "Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases", Proc. Natl. Acad. Sci. USA, 1996, 93, 14486-14491.
Ullrich, et al., "Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity", EMBO J., 1986, 5, 2503-2512.
Ware, et al., "Apoptosis Mediated by the TNF-Related Cytokine and Receptor Families", J. Cell. Biochem., 1996, 60, 47-55.

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