Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2006-08-08
2006-08-08
McElwain, Elizabeth F. (Department: 1638)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S471000, C536S023200
Reexamination Certificate
active
07087432
ABSTRACT:
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., DHA.
REFERENCES:
patent: 2363064 (2002-04-01), None
patent: WO 93/06712 (1993-04-01), None
patent: WO-98/03671 (1998-01-01), None
patent: WO 98/46764 (1998-10-01), None
patent: WO-98/46765 (1998-10-01), None
patent: WO 99/33958 (1999-07-01), None
patent: WO 99/33958 (1999-07-01), None
patent: WO 00/20602 (2000-04-01), None
patent: WO 00/20603 (2000-04-01), None
patent: WO-00/21524 (2000-04-01), None
patent: WO 00/34439 (2000-06-01), None
patent: WO-00/51444 (2000-09-01), None
patent: WO 00/75341 (2000-12-01), None
Broun et al, Science 282: 1315-1317, Nov. 13, 1998.
Van de Loo et al, PNAS, USA 92: 6743-6747, Jul. 1995.
Doerks et al, TIG 14(6): 248-250, Jun. 1998.
Smith et al, Nature Biotechnology 15: 1222-1223, Nov. 15, 1997.
Brenner, S.E., TIG 15(4): 132-133, Apr. 1999.
Bork et al, TIG 12(10): 425-427, Oct. 1996.
DeLuca, V, AgBiotech News and Information 5(6): 225N-229N, 1993.
Girke, T. et al. “Identification of a novel Δ6-acyl-group desaturase by targeted gene disruption inPhyscomitrella patens” The Plant Journal15(1):39-48 (1998).
Knutzon, Deborah S. et al. “Identification of Δ5-Desaturase fromMortierella alpinaby Heterologous Expression in Bakers' Yeast and Canola”The Journal of Biological Chemistry45(6):29360-29366 (1998).
Michaelson, Louise V. et al. “Functional identification of a fatty acid Δ5desaturase gene fromCaenorhabditis elegans” FEBS Letters439:215-218 (1998).
Michaelson, Louise V. et al. “Isolation of a Δ5-Fatty Acid Desaturase Gene fromMortierella alpina” The Journal of Biologica Chemistry273(30):19055-19059 (1998).
Napier, Jonathan A. et al. “Identification of aCaenorhabditis elegansΔ6-fatty-acid-desaturase by heterologous expression inSaccharomyces cerevisiae” Biochem. J.330:611-614 (1998).
Sayonova, Olga et al. “Expression of a borage desaturase cDNA containing an N-terminal cytochromeb5domain results in the accumulation of high levels of Δ6-desaturated fatty acids in transgenic tobacco”Proc. Natl. Acad. Sci. USA94:4211-4216 (Apr. 1997).
Watts, Jennifer L. et al. “Isolation and Characterization of a Δ5-Fatty Acid Desaturase fromCaenorhabditis elegans” Archives of Biochemistry and Biophysics362(1):175-182 (1999).
Hong, H. et al. “High-level production of γ-linolenic acid inBrassica junceausing a Δ6 desaturase fromPythium irregulare,” Plant Physiology, 129:354-362 (May 2002).
Qiu, X. et al. “Identification of a Δ4 fatty acid desaturase fromThraustochytriumsp. involved in the biosynthesis of docasahexanoic acid by heterologous expression inSaccharomyces cervisiaeandBrassica juncea,” Journal of Biological Chemistry, 276(34):331561-31566 (Aug. 24, 2001).
Bork, Peer, et al. “Go hunting in sequence databases but watch out for traps,”TIG, vol. 12(10):425-427 (1996).
Brenner, Steven E., “Errors in genome annotation,”TIG, vol. 15(4):132-133 (1999).
Broun, Pierre, et al., “Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids,”Sciencevol. 282:1315-1317 (1998).
Doerks, Tobias, et al., “Protein annotation: detective work for function prediction,”TIG, vol. 14(6):248-250 (1998).
Saito, Tomao, et al., “Identification of Δ5-fatty acid desaturase from the cellular slime moldDictyostelium discoiduem,” Eur. J. Biochem., vol. 265:809-814 (1999).
Smith, Temple F., et al., The challenges of genome sequence annotation or, “The devil is in the details,”Nature Biotechnology, vol. 15:1222-1223 (1997).
Sperling, Petra, et al., “A bifunctional Δ6-fatty acyl acetylenase/desaturase from the mossCeratodon purpureus,” Eur. J. Biochem., vol. 267:3801-3811 (2000).
Hong Haiping
Qiu Xiao
Bioriginal Food & Science Corp.
DiGiorgio, Esq. Jeanne M.
Hanley, Esq. Elizabeth A.
Lahive & Cockfield LLP
McElwain Elizabeth F.
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