Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1995-08-31
2000-01-18
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
435194, 530350, C12Q 148, C12N 912, C07K 100
Patent
active
060156821
ABSTRACT:
Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory SRB proteins are described. These holoenzymes will selectively initiate transcription in vitro when supplemented with general transcription factors such as TATA-binding protein (TBP) and factor a (TFIIE). The SRB proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.
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Chao David M.
Koleske Anthony J.
Thompson Craig M.
Young Richard A.
Stole Einar
Wax Robert A.
Whitehead Institute for Biomedical Research
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