Factor Xa inibitor from leech and pharmaceutical compositions co

Details Factor Xa inibitor from leech and pharmaceutical compositions co Factor Xa inibitor from leech and pharmaceutical compositions co

1989-06-23

1993-01-26

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Body fluid or exudate or transudate other than snake venom,...

424550, 530855, 514 21, A61K 3562

Patent

active

051821133

ABSTRACT:
A novel anticoagulant/modulator factor isolated from the saliva of the medicinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin.

REFERENCES:
patent: 4588587 (1986-05-01), Gasic
patent: 4791100 (1988-12-01), Kramer et al.
patent: 4832849 (1989-05-01), Cardin
Condra et al., Thrombosis and Haemostatis 61(3):437-441 (1989) (Exhibit C).
Baskova, I. P.; Nikonov, G. I. "Antithrombotic effect of salivary gland secretion and of other preparations from Hirudo medicinalis after intravenous and peroral administrations into rats", Chemical Abstracts 106 (No. 9), Abstract No. 60996w (Mar. 2, 1987) and Vopr. Med. Khim. 32(6): 90-93 (1986) (Russ.).
Gasic, G. J. et al., Cancer Res. 43: 1633-1636 (1983).
Gasic, G. J. et al., Cancer Res. 44: 5670-5676 (1984).
Abstract 110: 185955w, Gasic, G. J. et al. (1986).

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