Factor VIII/vWF complexes and compositions

Details Factor VIII/vWF complexes and compositions Factor VIII/vWF complexes and compositions

2005-10-11

2005-10-11

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S350000, C530S412000, C530S413000, C514S002600, C514S012200, C514S021800, C514S834000, C435S069100, C210S625000

Reexamination Certificate

active

06953837

ABSTRACT:
There is disclosed a method of recovering factor VIII/vWF-complex which is characterized in that factor VIII/vWF-complex from a protein solution is bound to a cation exchanger and is recovered by step-wise elution of factor VIII/vWF-complex, which particularly contains high-molecular vWF multimers, as well as a factor VIII/vWF-complex obtainable by means of cation exchange chromatography.

REFERENCES:
patent: 4578218 (1986-03-01), Saundry et al.
patent: 5679776 (1997-10-01), Burnouf-Radosevich et al.
patent: 5789153 (1998-08-01), Falkner et al.
patent: 5858658 (1999-01-01), Haemmerle et al.
patent: 5876969 (1999-03-01), Fleer et al.
patent: 5877152 (1999-03-01), Fischer et al.
patent: 5880265 (1999-03-01), Fischer et al.
patent: 6103693 (2000-08-01), Fischer et al.
patent: 6228613 (2001-05-01), Fischer et al.
patent: 737986 (2001-09-01), None
patent: 2251558 (1998-10-01), None
patent: 35 04 385 (1985-08-01), None
patent: 0 131 740 (1985-10-01), None
patent: 0 295 645 (1988-12-01), None
patent: 0 416 983 (1991-03-01), None
patent: 0 600 480 (1994-06-01), None
patent: 0 714 987 (1996-06-01), None
patent: 0 714 988 (1996-06-01), None
patent: WO 91/13093 (1991-09-01), None
patent: WO 93/15199 (1993-08-01), None
patent: EP600480 (1993-12-01), None
patent: WO 96/10584 (1996-04-01), None
patent: EP705846 (1996-10-01), None
patent: WO 97/34930 (1997-09-01), None
patent: WO 97/39033 (1997-10-01), None
patent: WO 98/38219 (1998-09-01), None
Burnouf et al., Protein Expression and Purification, vol. 5, pp. 138-143, 1994.
Official Action for A 338/97, dated Sep. 1, 1997.
Official Action for A 338/97, dated Sep. 17, 1997.
Official Action for A 866/98, dated May 20, 1998.
International Search Report for PCT/AT 98/00043.
Berntorp, E.; Plasma Product Treatment In Various Types of von Willebrand's Disease ;Haemostasis; 1994; pp. 289-297; vol. 24.
Bourgois, A. et al.; “Blood-coagulation Factor (vWF) Complex”;Chem. Abs; 1986; p. 380; vol. 105; Abstract No. 178421n.
Harrison, R.H., et al.; “Chromatography of the VIII/vWF Complex on Dextran Sulphate Sepharose”;Trhomb. Res.; 1988; pp. 295-304; vol. 50.
Harrison, P., et al.; The Purification of the VIII/vWF Complex Using Dextran Sulfate Sepharose Chromatography;Chem. Abs.; 1990; p. 274; ; vol. 112; Abstract No. 11822b.
Koops, et al.; “Immunoaffinity Purification of Factor VIII/von Willebrand Factor Complex”;Chem. Abs.; 1992; p. 324; vol. 117; Abstract No. 3089f.
Lethagen, et al.; Pharmacokinetics and Hemostatic Effect of Different Factor VIII/von Willebrand Factor Concentrates in von Willebrand's Disease Type III;Ann. Hematol., 1992; pp. 253-259; vol. 65.
Mejan, O. et al.; Immunopurification of Human Factor VIII/vWF Complex From Plasma;Pharmaceuticals; 1983; p. 357; vol. 109; Abstract No. 115910h.
Ruttyn, Y. et al.; Chromatography of Human Plasma on Aminohexyl Sepharose: Separation of Factor VIII/vWF and Behavior of Factors II, VII, IX and X and Antithrombin III;Enxymes; 1989; p. 311; vol. 111; Abstract No. 149359s.
Saundry et al.; “The Interaction of the Factor VIII/von Willebrand Factor Complex with Immobilized Metal Affinity Chromatography (IMAC) Matrixes”;Biochem Methods; 1990; p. 252; ; vol. 112; Abstract No. 18400w.

Affiliated with

Also associated with

Rating

Factor VIII/vWF complexes and compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Factor VIII/vWF complexes and compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Factor VIII/vWF complexes and compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3484326