Factor VIII glycoforms

Details Factor VIII glycoforms Factor VIII glycoforms

2002-08-22

2008-12-02

Robinson, Hope A (Department: 1652)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C530S350000, C514S002600, C514S012200, C435S007100

Reexamination Certificate

active

07459525

ABSTRACT:
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.

REFERENCES:
patent: 4377513 (1983-03-01), Sugimoto et al.
patent: 4703008 (1987-10-01), Lin
patent: 4757006 (1988-07-01), Toole, Jr. et al.
patent: 4766075 (1988-08-01), Goeddel et al.
patent: 4816397 (1989-03-01), Boss et al.
patent: 4868112 (1989-09-01), Toole, Jr.
patent: 4965199 (1990-10-01), Capon et al.
patent: 4970300 (1990-11-01), Fulton et al.
patent: 5198349 (1993-03-01), Kaufman
patent: 5612213 (1997-03-01), Chan
patent: 5661008 (1997-08-01), Almstedt et al.
patent: 5804420 (1998-09-01), Chan et al.
patent: 5952198 (1999-09-01), Chan
patent: 6136599 (2000-10-01), Cho
patent: 6180108 (2001-01-01), Cho et al.
patent: 6358703 (2002-03-01), Cho et al.
patent: 6528286 (2003-03-01), Ryll
patent: 0 254 076 (1988-01-01), None
patent: 0260148 (1988-03-01), None
patent: 2 085 887 (1982-05-01), None
patent: WO91/09122 (1991-06-01), None
Wells, Biochemistry, vol. 29, pp. 8509-8517, 1990.
Seffernick et al., J. Bacteriology, vol. 183, pp. 2405-2410, 2001.
ReFacto BDD Factor VIII SQ Product Information Insert, Revised May 2002.
Sandberg, H., et al., Seminars in Hematology, vol. 38, No. 2, Suppl. 4, pp. 4-12 (2001).
Pu et al., Rapid Establishment of High-Producing Cell Lines Using Dicistronic Vectors and Glutamine Synthetase as the Selection Marker. Mol. Biotechnol. 10: 17-25, 1998.
Kane, S.E. Selection of Transfected Cells and Coamplification of Transfected Genes, Methods Mol. Biol. 62: 359-367, 1997.
Bebbington et al. High-Level Expression of a Recombinant Antibody from Myeloma Cells using a Glutamine Synthetase Gene as an Amplifiable Selection Marker. Bio/Technol. 10: 169-175, Feb. 1992.
Vehar et al., Structure of human factor VIII.Nature312:337-342 (Nov. 1984).
Wood et al., Expression of active human factor VIII from recombinant DNA clones.Nature312:330-337 (Nov. 1984).
Toole et al., Molecular cloning of a cDNA encoding human antihaemophilic factor.Nature312:342-347 (Nov. 1984).
Gitschier et al., Characterization of the human factor VIII gene.Nature312:326-330 (Nov. 1984).
Lenting et al., The life cycle of coagulation factor VIII in view of its structure and function.Blood92(11):3983-3998 (1998).
Thompson AR, Structure and function of the factor VIII gene and protein.Seminars in Thrombosis and Hemostasis29(1):11-22 (2003).
Tajima et al., Characterization of “B Domain” Lacked Recombinant Factor VIII.Proc. 6th Int. Symp. H.T.1990, 51-63.
Lollar, P. Structure and function of Factor VIII. InInhibitors to Coagulation Factors, L.M. Aledort et al, eds. New York: Plenum Press, 1995, pp. 3-17.
Lind, P. et al. Novel forms of B-domain-deleted recombinant factor VIII molecules: Construction and biochemical characterization.Eur. J. Biochem.232, 1995, 19-27.
Cho et. al., Establishment of a Human Somatic Hybrid Cell Line for Recombinant Protein Production.Journal of Biomedical Science(2002).
Ragheb, J.A., et al., “The Amphotropic and Ecotropic Murine Leukemia Virus Envelope TM Subunits are Equivalent Mediators of Direct Membrane Fusion: Implications for the Role of the Ecotropic Envelope and Receptor in Syncytium Formation and Viral Entry”, Journal of Virology, 1995, vol 69, No. 11, pp. 7205-7215.
Walls et al., Amplification of multicistronic plasmids in the human 293 cell line and secretion of correctly processed recombinant human protein C.Gene, 1989, vol. 81, pp. 139-149.
Stillman et al., Replication and Supercoiling of Simian Virus 40 DNA in Cell Extracts from Human Cells.Molecular and Cellular Biology, Aug. 1985, vol. 5, No. 8, pp. 2051-2060.
Peshwa et al., Cultivation of Mammalian Cells as Aggregates in Bioreactors: Effect of Calcium Concentration on Spatial Distribution of Viability.Biotechnology and Bioengineering, 1993, vol. 41, pp. 179-187.

Affiliated with

Also associated with

Rating

Factor VIII glycoforms does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Factor VIII glycoforms, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Factor VIII glycoforms will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4038422