Factor VIII coagulant polypeptides and monoclonal antibodies tof

Details Factor VIII coagulant polypeptides and monoclonal antibodies tof Factor VIII coagulant polypeptides and monoclonal antibodies tof

1985-09-20

1989-08-15

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530829, 514 2, 514 21, 514834, 424101, A61K 3702, C07K 1506

Patent

active

048576352

ABSTRACT:
Polypeptides have been discovered which exhibit high specific VIII:C coagulant activity. Monoclonal antibodies to the polypeptides are also disclosed.

REFERENCES:
patent: 4657894 (1987-04-01), Zimmerman et al.
Fulcher et al, Proc Natl Acad Sci, Mar. 1982, vol. 79, pp. 1648-1652, "Characterization of the Human Factor VIII Procoagulant Protein with a Heterologous Precipitating Antibody".
Fass et al, Blood, vol. 59 (3), Mar. 1982, pp. 594-600, "Monoclonal Antibodies to Porcine Factor VIII Coagulant and Their Use in the Isolation of Active Coagulant Peptide".

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