Factor VIII binding domain of von Willebrand Factor

Details Factor VIII binding domain of von Willebrand Factor Factor VIII binding domain of von Willebrand Factor

1991-07-03

1993-11-09

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 8, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 530325, 530326, 530327, 530328, 530329, 530330, 530331, 530350, 530380, 530381, 530383, 530324, A61K 3702, C07K 710

Patent

active

052602745

ABSTRACT:
Peptides which inhibit the binding of von Willebrand Factor to Factor VIII. Monoclonal antibodies capable of specifically binding to the region of von Willebrand Factor containing the Factor VIII binding domain. Improved methods of preparing Factor VIII.

REFERENCES:
patent: 5043429 (1991-08-01), Zimmerman et al.
Titani, K. et al., Biochemistry, 25: 3174-3184, 1986.
Sadler, J. et al., Proc. Natl. Acad. Sci., USA 82: 6394-6398, Oct. 1985.
Alberts et al., Molecular Biology of the Cell, Garland Publishing Inc., pp. 185-196, 1983.
Stewart et al., Solid Phase Peptide Synthesis, 2nd ed., Pierce Chemical Co., 1984.

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