Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1991-06-26
1992-05-12
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530395, 514 8, 514 12, 435 696, C07K 1300, A61K 3700
Patent
active
051129507
ABSTRACT:
Factor VIII analog which has undergone deletion of amino acids 771 to 1666, prepared from eukaryotic cells transformed by an expression vector carrying the cDNA of the factor VIII which has undergone deletion.
REFERENCES:
Brickhouse et al., "Purified Human Factor VIII Procoagulant Protein: Comparative Hemostatic Response After Infusions into Hemophilic and von Willebrand Disease Dogs", Proc. Natl. Acad. Sci., vol. 82 (Dec. 1985), 8752-8756.
Vehar et al., "Structure of Human Factor VIII", Nature, vol. 312 (Nov. 1984), p. 337.
Leyte et al., "The Interaction Between Human Blood-Coagulation Factor VIII and von Willebrand Factor", Biochem. J., 257 (1989), pp. 679-683.
Foster et al., "An immunogenic Region Within Residues Val.sup.1670 -Glu.sup.1684 of the Factor VIII Light Chain Induces Antibodies Which Inhibit Binding of Factor VIII to von Willebrand Factor", J. of Biological Chemistry, vol. 263, No. 11 (Apr. 1988), pp. 5230-5234.
Foster et al., "A Synthetic Factor VIII Peptide of Eight Amino Acid Residues (1677-1684) Contains the Binding Region of an Anti-Factor VIII Antibody which Inhibits the Binding of Factor VIII to von Willebrand Factor," Thrombosis and Haemostasis--F. K. Schattauer Verlagsgesellschaft mbH. pp. 403-406.
French Search Resport, Apr. 1988.
Toole et al.: "A Large Region (95 kDa) of Human Factor VIII is Dispensible for in Vitro Procoagulant Activity", Proc. Natl. Acad. Sci. USA, vol. 83, pp. 5939-5942, Aug. 1986, Biochemistry.
Eaton et al.: "Construction and Characterization of an Active Factor VIII Variant Lacking the Central One-Third of the Molecule", Biochemistry, vol. 25, No. 26, Dec. 30, 1986.
Meulien Pierre
Pavirani Andrea
Baker R. Keith
Transgene S.A.
Wax Robert A.
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