Factor VII/VIIA active site inhibitors

Details Factor VII/VIIA active site inhibitors Factor VII/VIIA active site inhibitors

1989-03-13

1991-06-11

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, A61K 3702, C07K 508

Patent

active

050232363

ABSTRACT:
The invention includes a class of compounds that inhibit the specific proteolytic activity of the bimolecular complex 1[TF:VII/VIIa] that initiates the blood coagulation systems. Both reversible and irreversible inhibitors are disclosed.
The invention encompasses the use of inhibitors of the active site of the factor VII and VIIa component of [TF:VII/VIIa] as diagnostic reagents, as analytical reagents, and as therapeutic drugs.
The invention includes the compounds based on the following general formula for both reversible and irreversible selective inhibition of [TF:VII/VIIa]. ##STR1##

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