Factor VII polypeptide having factor VII:C activity

Details Factor VII polypeptide having factor VII:C activity Factor VII polypeptide having factor VII:C activity

2005-07-19

2005-07-19

Carlson, Karen Cochrane (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C435S013000, C435S069600, C435S320100, C435S253300, C435S242000, C536S023400, C536S023500

Reexamination Certificate

active

06919311

ABSTRACT:
Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.

REFERENCES:
patent: 5364771 (1994-11-01), Lollar et al.
Pipe S. W. (1996) Factor VIII C2 domain missense mutations exhibit trafficking of biologically functional proteins. J Biol Chem. vol. 271, pp. 25671-25676.
Eaton, D. L. et al. (1986) Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule. Biochemistry. vol. 25, pp. 8343-8347.
Lenting P. J. (1999) The light chain of factor VIII comprises a binding site for low density lipoprotein receptor-related protein. J Biol Chem. vol. 274, pp. 23734-23739.
Liu, M. L. et al. (2000) Hemophilic factor VIII C1- and C2-domain missense mutations and their modeling to the 1.5-angstrom human C2-domain crystal structure. Blood vol. 96, pp. 979-987.
Schwarz, H. P. et al. (2000) Involvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor-deficient mice. Blood. vol. 95, pp. 1703-1708.
Willnow, T. E. et al. (1999) Lipoprotein receptors: new roles for ancient proteins.Nature Cell Biol. vol. 1, pp. E157-E162. Review.

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