Factor sensitive reagent for testing of blood coagulation contai

Details Factor sensitive reagent for testing of blood coagulation contai Factor sensitive reagent for testing of blood coagulation contai

1989-03-21

1991-10-08

Hill, Jr., Robert J.

Chemistry: analytical and immunological testing

Clotting or clotting factor level tests

435 13, G01N 3386

Patent

active

050554123

ABSTRACT:
The present invention involves a partial thromboplastin time test reagent which is factor sensitive depending upon the selected reagent constituents. A method for peparing such reagent is also disclosed. The present invention further involves a procoagulant precursor reagent and a method of making it. The factor sensitive reagent is of exceptional stability enabling more precise partial prothrombin time measurements. The reagents contain ellagic acid or an ellagic acid salt and divaent metal ions in a specific molar ratio relative to the ellagic acid or ellagic acid salt.

REFERENCES:
patent: 3486981 (1969-12-01), Speck
patent: 4732860 (1988-03-01), Bartl et al.
Activation of Intrinsic Blood Coagulation by Ellagic Acid: Insoluble Ellagic Acid-Metal Ion Complexes are the Activating Species, Biochemistry (1981), 20, 7258-7265.
Ratnoff et al, J. Lab. Clin. Med., vol. 63, No. 3, pp. 359-377, Mar. 1964.

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