Factor IX- polymeric conjugates

Details Factor IX- polymeric conjugates Factor IX- polymeric conjugates

1993-06-08

1997-04-15

Mullis, Jeffrey C.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 542, 530381, A61K 3800

Patent

active

056210396

ABSTRACT:
Conjugates containing a substance with coagulant activity, such as recombinant Factor IX, non-antigenic polymers, such as poly(ethylene glycol), are disclosed. Also disclosed are methods of forming the novel conjugates of this invention.

REFERENCES:
patent: 3717708 (1973-02-01), Wada et al.
patent: 4970300 (1990-11-01), Fulton et al.
patent: 5153265 (1992-10-01), Shadle et al.
Busby et al. Expression of Active Human Factor IX in Transfected Cells, Nature, vol. 316, Jul., 1985, pp 271-273.
Kaufman et al., Expression, Purification and Characterization of Recombinant .gamma.-Carboxylated Factor IX Synthesized in Chinese Hamster Ovary Cells, The Journal of Biological Chemistry, vol. 261, No. 21, Jul., 1986, pp 9622-9628.
Hertzberg et al., Construction, Expression, and Characterization of a Chimera of Factor IX and Factor X, The Journal of Biological Chemistry, vol. 267, No. 21, Jul., 1992 pp. 14759-14766.

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