Factor-dependent hematopoietic cell line exhibiting epo-induced

Details Factor-dependent hematopoietic cell line exhibiting epo-induced Factor-dependent hematopoietic cell line exhibiting epo-induced

1989-10-27

1992-07-07

Doll, John

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352401, 43524025, 435948, C12N 500, C12N 502, C12N 100

Patent

active

051282593

ABSTRACT:
Factor-dependent cell line, HU-01, provides the first in vitro system in which human CD34 positive hematopoietic cells have been induced to undergo complete differentiation into enucleated hemoglobin-containing erythrocytes. HU-01 cells may provide a source of monoclonal antibodies useful for early diagnosis and possible treatment of human leukemia conditions, as well as of regulatory factors having therapeutic utility.

REFERENCES:
Morgan et al., "Novel peripheral blood-derived human cell lines with properties of megakaryocytes", The Journal of Cell Biol., vol. 100, 565-573, 1985.

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