Facilitation of resuscitation from cardiac arrest by...

Details Facilitation of resuscitation from cardiac arrest by... Facilitation of resuscitation from cardiac arrest by...

2009-11-06

2011-11-29

Kemmerer, Elizabeth C (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S395000, C514S016400

Reexamination Certificate

active

08067366

ABSTRACT:
The present invention relates generally to the use of erythropoietin (EPO) to facilitate resuscitation from cardiac arrest. For a mammalian subject suffering from cardiac arrest, concurrent administration of EPO with resuscitation after the onset of ventricular fibrillation facilitates the resuscitation. Administration of EPO serves to attenuate myocardial abnormalities caused by cardiac arrest and the resuscitation efforts and favor improved resuscitation outcomes. The main effect of EPO that facilitates resuscitation is the preservation of left ventricular myocardial distensibility leading to improve left ventricular preload and the amount of blood ejected by chest compression. This effect enables higher coronary perfusion pressures to be generated resulting in a higher rate of return of spontaneous circulation and higher survival rates. The very same effect enables the return of spontaneous circulation to occur faster reducing the time a human subject is in cardiac arrest. These effects lead to a higher number of cardiac arrest victims to survive and to do so with intact neurological function in most of the survivors.

REFERENCES:
patent: 3552390 (1971-01-01), Muller
patent: 7309687 (2007-12-01), Brines et al.
patent: 2003/0104988 (2003-06-01), Brines et al.
Mitra et al. N-linked oligosaccharides as outfitters for glycoprotein folding, form and function. TRENDS in Biochemical Sciences, vol. 13 No. 3:156-163 (2006).
Boissel et al. Erythropoietin structure-function relationships. The Journal of Biological Chemistry, vol. 268, No. 21:15983-15993 (1993).

Affiliated with

Also associated with

Rating

Facilitation of resuscitation from cardiac arrest by... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Facilitation of resuscitation from cardiac arrest by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Facilitation of resuscitation from cardiac arrest by... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4302810