Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-01-29
1999-11-09
Duffy, Patricia A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
4242441, A01K 4304, A61K 31715
Patent
active
059815086
ABSTRACT:
Neural injury of the type resulting from trauma or surgery may be advantageously treated with a polysaccharide toxin derived from Group B .beta.-hemolytic Streptococcus (GBS) bacteria. Additionally, diseases characterized by neuronal degeneration or impairment of neuronal connectivity, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis may be treated with the GBS toxin. The GBS toxin is administered to the patient before, during, or after infliction of the neural injury and acts by minimizing gliosis and promoting the reestablishment of neuronal connectivity.
REFERENCES:
patent: 4242326 (1980-12-01), Sugawara et al.
patent: 4882317 (1989-11-01), Marburg et al.
patent: 4895838 (1990-01-01), McCluer et al.
patent: 5010062 (1991-04-01), Hellerqvist et al.
patent: 5225331 (1993-07-01), Jennings et al.
patent: 5302386 (1994-04-01), Kasper et al.
patent: 5382514 (1995-01-01), Passaniti et al.
Augustin, H. G., et al., Ovarian Angiogenesis: Phenotypic Characterization of Endothelial Cells in a Physiological Model of Blood Vessel Growth and Regression, Am. J. Pathol., 147(2):339-351, (1995).
Battegay, E. J., Angiogenesis: Mechanistic Insights, Neovascular Diseases, and Therapeutic Prospects, J. Mol. Med., 73:333-346, (1995).
Brown, L. F., et al., Overexpression of Vascular Permeability Factor (VPF/VEGF) and its Endothelial Cell Receptors in Delayed Hypersensitivity Skin Reactions, J. Immunol., 154(6):2801-2807, (1995).
Brown, L. F., et al., Increased Expression of Vascular Permeability Factor (Vascular Endothelial Growth Factor) in Bullous Pemphigoid, Dermatitis Herpetiformis, and Erythema Multiforme, J. Invest. Dermatol., 104(5):744-749, (1995).
Cheng, H., et al., Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function, Science, 273:510-513 (1996).
Dvorak, H. F., et al., Vascular Permeability Factor/Vascular Endothelial Growth Factor: An Important Mediator of Angiogenesis in Malignancy and Inflammation, Int. Arch. Allergy Immunol, 107:233-235, (1995).
Dvorak, H. F., et al., Vascular Permeability Factor/Vascular Endothelial Growth Factor, Microvascular Hyperpermeability, and Angiogenesis, Am. J. Pathol., 146(5):1029-1039, (1995).
Ferrara, N., The Role of Vascular Endothelial Growth Factor in Pathological Angiogenesis, Breast Cancer Res. Treat., 36:127-137, (1995).
Ferrara, N., et al., Vascular Endothelial Growth Factor, a Specific Regulator of Angiogenesis, Curr. Opin. Nephrol. Hypertens, 5(1):35-44, (1996).
Folkman, J., Angiogenesis in Cancer, Vascular, Rheumatoid and Other Disease, Nature Medicine, 1(1):27-31, (1995).
Folkman, J., Diagnostic and Therapeutic Applications of Angiogenesis Research, C. R. Acad. Sci. Paris, Sciences de la vie, 361:914-918, (1993).
Folkman, J., et al., Angiogenic Factors, Science, 235:442-447, (1987).
Hellerqvist, C.G., et al., Early Results of a Phase I Trial of CM101 in Cancer Patients, Proceedings of the American Assoc. of Cancer Research Annual Meeting, 36:224, (1995).
Hellerqvist, C.G., et al., Studies on Group B .beta.-Hemolytic Streptococcus I. Isolation and Partial Characterization of an Extra-Cellular Toxin, Pediatr. Res., 15:892-898, (1981).
Hellerqvist, C.G., et al., Cytokine Production in Cancer Patients Receiving the Anti-Neovascularization Drug CM-101, Proceedings of ASCO, Abstract #1592, vol. 14, (1995).
Hellerqvist, C.G., et al., Antitumor Effects of GBS Toxin: a Polysaccharide Exotoxin From Group B .beta.-Hemolytic Streptocuccus, J. Canc. Res. Clin. Oncol., 120:63-70, (1993).
Hellerqvist, C.G., et al., CM101 Induces a Complement-Activated Inflammatory Response Targeting Tumor Neovasculature, Proceedings of the American Assoc. for Cancer Research, Abstract #3328, (1996).
Herblin, W., et al., Inhibition of Angiogenesis as a Stragegy for Tumor Growth Control, Molecular and Chemical Neuropathology, 21:329-336, (1994).
Houle, J.D., et al., Axonal Regeneration by Chronically Injured Supraspinal Neurons Can be Enhanced by Exposure to Insulin-Like Growth Factor, Basic Fibroblast and Growth Factor of Transforming Growth Factor Beta, Restorative Neurol. and Neurosci., 10:205-215, (1996).
Jennings, H. J., et al., Structural Determination and Serology of the Native Polysaccharide Antigen of Type-III Group .beta.-Streptococcus.sup.1, Can J. Biochem., 58(2):112-120, (1980).
Kim, K.J., et al., Inhibition of Vascular Endothelial Growth Factor-Induced Angiogenesis Suppresses Tumour Growth In Vivo, Nature, 362:841-844, (1993).
Klagsbrun, M., et al., Regulators of Angiogenesis, Annu. Rev. Physiol., 53:217-239, (1991).
Mollgard, K, et al., Development of Spinal Cord in the Isolated CNS of a Neonatal Mammal (the Opossum Menodelphis Domestica) Maintained in Longterm Culture, J. Neurocyt., 23:151-165, (1994).
Moses, M. A., et al., Identification of an Inhibitor of Neovascularization From Cartilage, Science, 248:1408-1410, (1990).
Nicholls, J.G, et al., Reflexes, Fictive Respiration and Cell Division in the Brain and Spinal Cord of the Newborn Opossum, Monodelphis Domestica, Isolated and Maintained in Vitro, J. Exp. Biol., 152:1-15, (1990).
Nicholls, J., et al., Regeneration of Immature Mammalian Spinal Cord After Injury, Trends Neurosci, 19(6):229-234, (1996).
Ondrick, K., Ph.D., et al., Angiogenesis, Clinics in Podiatric Medicine and Surgery, 9(1):185-203, (1992).
Ono, M., et al., Induction of Human Microvascular Endothelial Tubular Morphogenesis by Human Keratinocytes: Involvement of Transforming Growth Factor-Alpha, Biochem. Biophys. Res. Commun., 189(2):601-609 (1992).
Parkinson, D. R., Present Status of Biological Response Modifiers in Cancer, Amer. J. Med., 99 (Suppl. 6A):54S-56S, (1995).
Plate, K. H., et al., Molecular Mechanisms of Developmental and Tumor Angiogenesis, Brain Pathol., 4:207-218, (1994).
Polverini, P.J, The Pathophysiology of Angiogenesis, Crit. Rev. Oral Biol. Med. , 6(3):230-247, (1995).
Sato, N., et al., Actions of TNF and IFN-.gamma. in Angiogenesis In Vitro, J. Invest. Derm., 95(6 Supp.):85S-89S, (1990).
Seil, F.J., Neural Regeneration: 6th International Symposium, The Neuroscientist, 2(3):143-44, (1996).
Senger, D. R., et al., Vascular Permeability Factor (VPF, VEGF) in Tumor Biology, Cancer and Metastasis Reviews, 12:303-324, (1993).
Senger, D. R., et al., Vascular Permeability Factor, Tumor Angiogenesis and Stroma Generation, Invasion Metastasis, 14:385-394, (1994-1995).
Stewart R.R., et al., The Intact Central Nervous System of the Newborn Opossum in Long-Term Culture: Fine Structure and GABA-Mediated Inhibition of Electrical Activity, J. Exp. Biol., 161:25-41, (1991).
Sotelo, C., et al., The Reconstruction of Cerebellar Circuits, Trends Neurosci., 14(8):350-355, (1991).
Turco, S.J., Intravenous Admixtures, Remington's Pharmaceutical Sciences, 18th ed., chapter 85:1570-1580, Mach Publ., (1990).
van den Pol, A.N., et al., Excitatory Actions of GABA After Neuronal Trauma, J. Neurosci., 16(13):4283-4292, (1996).
Wamil, B.D., et al., Leukocyte Activation in Response to CM101 Treatment of Cancer Patients, Proceedings of the American Assoc. for Cancer Research, Abstract #3329, (1996).
Wamil, A., et al., Phenytoin Blocks N-Methyl-D-Aspartate Responses of Mouse Central Neurons, J. Pharmacol. Exp. Ther., 267(1):218-227, (1993).
Wamil et al., Use-, Concentration-, and Voltage-Dependent Limitation by MK-801 of Action Potential Firing Frequency in Mouse Central Neurons in Cell Culture, J. Pharmacol. Exp. Ther., 260:376-383, (1991).
Wamil, A.W., et al., Effect of Temperature on Limitation by MK-801 of Firing of Action Potentials by Spinal Cord Neurons in Cell Culture, European J. of Pharmacol., 230:263-269, (1993).
Ye, Jian-Hui, et al., Treatment of the Chronically Injured Spinal Cord with Neurotrophic Factors Can Promote Axonal Regeneration From Supraspinal Neurons, Experimental Neurology, 143:70-81, (1997).
Young, Wise, Spinal Cord Regeneration, Science, 273:451, (1996).
Zhoa, S., et al., Neurotization of Motor Nerves Innervating the Lower Extremity by Utilizing the Lower Intercostal Nerves, J. of Reconstructive Microsurgery, 13(1):39-45, (1997).
Hellerqvist
Hellerqvist Carl G.
Wamil Artur W.
Wamil Barbara D.
Duffy Patricia A.
Vanderbilt University
LandOfFree
Facilitation of repair of neural injury with CM101/GBS toxin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Facilitation of repair of neural injury with CM101/GBS toxin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Facilitation of repair of neural injury with CM101/GBS toxin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1456104