Facilitation of AMPA receptor-mediated synaptic transmission in

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142232, 5142292, 514249, 514321, 514322, 514338, 514354, 514410, 514411, 514423, A61K 3155, A61K 3154

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active

057734348

ABSTRACT:
Psychotic symptoms are treated by the administration of drugs which amplify the ability of natural stimulators of AMPA receptors to enhance the mediation of excitatory synaptic response. What is previously known about the activity and effectiveness of these drugs is unrelated to the etiology of psychotic symptoms. The invention finds particular utility in the treatment of schizophrenia.

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Hcaplus abstract, AN 1995:66274 (1994) Cordi, A.A. et al.
Pirotte, et al., "New Pyridothiadiazines, Processes for their Preparation, and Pharmaceutical Compositions Containing Them," Chemical Abstract No. 290897z, 122(23):1042, Jun. 5, 1995.

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