Facile synthesis of L-homophenylalanine by equilibrium shift enz

Details Facile synthesis of L-homophenylalanine by equilibrium shift enz Facile synthesis of L-homophenylalanine by equilibrium shift enz

1999-08-27

2000-11-14

Pronty, Rebecca E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435106, C12P 1322, C12P 1304

Patent

active

061468592

ABSTRACT:
A process for producing L-homophenylalanine comprises the step of reacting 2-oxo-4-phenylbutyric acid with a L-amino acid in the presence of tyrosine aminotransferase in a reaction solution to produce L-homophenylalanine.

REFERENCES:
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Shui-Tein Chen et al., "Kinetic Resolution of N-Protected Amino Acid Esters in Organic Solvents Catalyzed By A Stable Industrial Alkaline Protease" Biotechnol. Lett. vol. 13(11), 1991, pp. 773-778.
Ching-Shih Chen et al., "Quantitative Analyses of Biochemical Kinetic Resolution of Enantiomers" J. Am. Chem. Soc. vol. 104, 1982, pp. 7294-7298 .

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