Facile synthesis of codeine precursors from thebaine

Details Facile synthesis of codeine precursors from thebaine Facile synthesis of codeine precursors from thebaine

1980-01-25

1981-07-07

Satto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 45, C07D48902

Patent

active

042776040

ABSTRACT:
Thebaine is converted to a mixture of codeinone and neopinone in aqueous formic acid solution containing as catalyst a mercuric salt. Thebaine is converted to a neopinone ketal by irradiation in an alkanol or to a mixture of neopinone and codeinone in an acidic aqueous solution. Neopinone ketals, codeinone and neopinone can be converted to codeine.

REFERENCES:
patent: 3112323 (1963-11-01), Krausz
patent: 4054566 (1977-10-01), Rapoport et al.
patent: 4110329 (1978-08-01), Rapoport et al.
Gavard, et al., Bull. Soc. Chim. France, (1965), pp. 486-490.
Barber, et al., J. Med. Chem., vol. 19, No. 10, pp. 1175-1180, (1976).
Samchenko, et al., Chemical Abstracts, vol. 69, 85862e, (1968).

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