Facile process for the preparation of high-purity aminopterin

Details Facile process for the preparation of high-purity aminopterin Facile process for the preparation of high-purity aminopterin

2007-06-26

2007-06-26

Jiang, Shaojia Anna (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Plural nitrogens bonded directly to the pteridine ring system

Reexamination Certificate

active

11619102

ABSTRACT:
A process for the preparation of aminopterin with a purity greater than 90%, which comprises reacting folic acid, with a silazane in an organic solvent at a temperature from 60 to 180° C., the said solvent being a tertiary amine organic solvent, or, if a catalyst which is acid in nature is present, a basic organic solvent or acetonitrile, and further adding water such that there is about 2.8 to 7.0 mole water for each mole of folic acid.

REFERENCES:
patent: 4767859 (1988-08-01), Zimmermann

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