Facile condensation of methylbenzoxazoles with aromatic aldehyde

Details Facile condensation of methylbenzoxazoles with aromatic aldehyde Facile condensation of methylbenzoxazoles with aromatic aldehyde

1992-10-14

1994-03-01

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 14, 548110, 548217, C07D41306, C07D21186

Patent

active

052909417

ABSTRACT:
An efficient process for the preparation of styrylbenzoxazoles and derivatives thereof comprises reacting a methylbenzoxazole with an aromatic aldehyde in the presence of strong base at low temperature, followed by warming. The condensation products are inhibitors of H.sup.+ K.sup.+ -ATPase, and are also useful as penultimate compounds in the preparation of inhibitors of HIV reverse transcriptase.

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