Face-to-face/face-to-edge interactive chiral selectors and relat

Details Face-to-face/face-to-edge interactive chiral selectors and relat Face-to-face/face-to-edge interactive chiral selectors and relat

1995-06-06

1997-10-07

Therkorn, Ernest G.

Liquid purification or separation

With means to add treating material

Chromatography

2105021, 210635, 210656, 502401, B01D 1508

Patent

active

056743874

ABSTRACT:
The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsteroidal anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

REFERENCES:
patent: 4318819 (1982-03-01), Malloy
patent: 4318820 (1982-03-01), Malloy
patent: 4322310 (1982-03-01), House
patent: 4512898 (1985-04-01), Oi
patent: 4604207 (1986-08-01), Oi
patent: 4818394 (1989-04-01), Okamoto
patent: 4824950 (1989-04-01), Barcza
patent: 4909935 (1990-03-01), Bradshaw et al.
patent: 4919803 (1990-04-01), Doyle et al.
patent: 4959935 (1990-10-01), Bradshaw et al.
patent: 5080795 (1992-01-01), Pirkle
patent: 5256293 (1993-10-01), Pirkle
patent: 5387338 (1995-02-01), Pirkle
patent: 5484530 (1996-01-01), Pirkle
Bojarski (1989) "Chromatography of Enantiomers of 2-Arylpropionic Acids", Journal of Liquid Chromatography 12:2685-2706.
Castro, et al. (1989) "Chiral Recognition in Clefts and Cyclophane Cavities Shaped by the 1,1'-Binaphythyl Major Groove", J. Org. Chem. 54:5835-5838.
Crossland, et al. (1970) "A Facile Synthesis of Methanesulfonate Esters", J. Org. Chem. 35:3195-3196.
Dharanipragada, et al. (1987) "Diastereomeric Complex Formation Between a Novel Optically Active Host and Naproxen in Aqueous Solution", Tetrahedron Letters 28:2443-2446.
Dharanipragada, et al. (1988) "A Novel Optically Active Host: Design Computer Graphics, Synthesis and Diastereomeric Complex Formation in Aqueous Solution", J. Am. Chem. Soc. 110: 1679-1690.
Doyle, et al. (1985) "The Resolution of Enantiomeric Drugs Using HPLC Chiral Stationary Phases", Pharmaceutical Technology:28-32, undated.
Georgiadis, et al. (1991) "Synthesis and Complexation Properties of a Water-Soluble Optically Active Cyclophane Incorporating 4-Naphthyl-1,2,3,4-Tetrahydroisoquinoline Unit as a Chiral Spacer", J. Org. Chem. 56:3362-3369.
Hermansson, et al. (1986) "Direct Liquid Chromatographic Resolution of Acidic Drugs Using a Chiral .sub..alpha.1 -Acid Glycoprotein Column (Enantiopac.RTM.)", Journal of Liquid Chromatography 9:621-639.
Oi, et al. (1986) "Direct Separation of Underivatized .alpha.-Methylarylacetic Acid Enantiomers by High Performance Liquid Chromatography with Chiral Stationary Phase", Bunseki Kagaku 35:312-313.
Perry, et al. (undated) "Chiral Separations by HPLC. Theory and Practice: Developments with the Pirkle Covalent HPLC Column", No. 939. 1 page.
Pettersson, et al. (1988) "Improved Resolution of Enantiomers of Naproxen by the Simultaneous use of a Chiral Stationary Phase and a Chiral Additive in the Mobile Phase", Journal of Chromatography 435:225-228.
Pirkle, et al. (1988) "An Improved Chiral Stationary Phase for the Facile Separation of Enantiomers", Journal of Chromatography 441:311-322.
Pirkle, et al. (1988) "Chiral Separations", Plenum Press:23-25, Edited by Stevenson of Plenum Press New York.
Pirkle, et al. (1989) "Improved Chiral Stationary Phase for the Separation of the Enantiomers of Chiral Acids as their Anilide Derivatives", Journal of Chromatography 471:271-281.
Pirkle, et al. (1989) "Use of Achiral Ion-Pairing Reagents with Chiral Stationary Phases", Journal of Chromatography 479:377-386.
Pirkle, et al. (1990) "The Separation of the Enantiomers of a Variety of Non-Steroidal Anti-Inflammatory Drugs (NSaids) as their Anilide Derivatives Using A Chiral Stationary Phase", Journal of Liquid Chromatography 13:2123-2134.
Pirkle, et al. (1991) "A Chiral Stationary Phase which Affords Unusually High Levels of Enantioselectivity", Chirality 3:183-187.
Pirkle, et al. (1991) "A Convenient Void Volume Marker for Several Chiral HPLC Columns", Journal of Liquid Chromatography 14:1-8.
Pirkle, et al. (Jul. 3, 1992) "Design, Synthesis and Evaluation of an Improved Enantioselective Naproxen Selector", J. Org. Chem. 57:3854-3860.
Pirkle, et al. (1992) "An Improved Chiral Stationary Phase for the Chromatographic Separation of Underivatized Naproxen Enantiomers", Journal of Liquid Chromatography 15:1947-1955.
Rubin, et al. (1986) "Chiral Recognition in Aqueous Solution. Search for Water-Soluble Chiral Hosts with Apolar Binding Sites", J. Org. Chem. 51:3270-3278.
Schroeter, et al. (1929) "Uber Die Hydrierung Des Phenanthrens" 62, Ber. Der. Deutschen Chem.:645-658 (Germany).
Wainer, et al. (1983) "Resolution of Norephedrine as its 2-Oxazolidone Derivative: Enantiomeric Separation on a Chiral High-Performance Liquid Chromatographic Stationary Phase and Preparative Regeneration of the Resolved Isomers", Journal of Chromatography 268:107-111.
Wainer, et al. (1984) "Application of High-Performance Liquid Chromatographic Chiral Stationary Phases to Pharmaceutical Analysis: Structural and Conformational Effects in the Direct Enantiomeric Resolution of .alpha.-Methylarylacetic Acid Anti-Inflammatory Agents", J. of Chrom. 284:117-124.
Wainer, et al. (1984) "The Application of HPLC Chiral Stationary Phases to Pharmaceutical Analysis: The Resolution of Some Tropic Acid Derivatives", Journal of Liquid Chromatography 7:731-741.
Wainer, et al. (undated) "Stereoisomeric Separations: Use of Chiral Stationary Phases to Resolve Molecules of Pharmacological Interest", LC 2(2):88-98. (undated).
Yang, et al. (1985) "Application of High-Performance Liquid Chromatographic Chiral Stationary Phases to Pharmaceutical Analysis", Journal of Chromatography 324:444-449.
"One Optical Isomer Without the Other" (1985) Chemical Week:28-29, Feb. 13, 1985.
Search Report for PCT/US92/08006, Dec. 21, 1992, pp. 1-5.

Affiliated with

Also associated with

Rating

Face-to-face/face-to-edge interactive chiral selectors and relat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Face-to-face/face-to-edge interactive chiral selectors and relat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Face-to-face/face-to-edge interactive chiral selectors and relat will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2353904