Fabrication of living blood vessels and glandular tissues

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Stent structure

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128 1R, 435 1, 623 2, 623 12, 623 14, A61F 100

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045465002

ABSTRACT:
A method and apparatus for producing a vessel-equivalent prosthesis is described. A contractile agent such as fibroblast cells, smooth muscle cells or platelets is incorporated into a collagen lattice and contracts the lattice axially around an inner core. After the structure has set, additional layers may be formed in an ordered manner depending on the intended function of the prosthesis. Alternatively, all the layers may be formed concurrently. A plastic mesh sleeve is sandwiched between layers or embedded within the smooth muscle cell layer to reinforce the structure and provide sufficient elasticity to withstand intravascular pressure.

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Sarber, R. et al., "Regulation of Proliferation of Fibroblasts of Low and High Population Doubling Levels Grown in Collagen Lattices", Mech. _Ageing & Dev. 17, 107-117 (1981).
Bell, Eugene et al., "Development and Use of a Living Skin Equivalent", J. Plastic & Reconstructive Surgery 67, 386-392 (1981).
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Ehrmann et al., J. Nat'l. Canc. Inst., vol. 16 (1956), pp. 1375-1403.
Michalopoulos et al., Experm. Cell. Res., vol. 94 (1975), pp. 70-78.

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