Fabrication and integration of polymeric bioMEMS

Active solid-state devices (e.g. – transistors – solid-state diode – Responsive to non-electrical signal

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C257S040000

Reexamination Certificate

active

07375404

ABSTRACT:
A micro-electro-mechanical system (MEMS) device is provided, along with means for its fabrication and operation for microfluidic and/or biomicrofluidic applications. The MEMS device includes a substrate, optional electrodes on the substrate, a patterned structure on the substrate, the patterned structure having a fluidic microchannel aligned with one or more of the optional electrodes, an encapsulation membrane covering the microchannel, and an optional reactive layer deposited over the electrode in the microchannel. MEMS devices of preferred embodiments permit a leak-tight seal to be formed around the microchannel and fluidic interconnects established for robust operation of fluidics-based processes. MEMS devices of other preferred embodiments permit reversible attachment and separation of the encapsulation membrane relative to the patterned structure.

REFERENCES:
patent: 4148689 (1979-04-01), Hino et al.
patent: 5015576 (1991-05-01), Nilsson et al.
patent: 5147698 (1992-09-01), Cole
patent: 5422116 (1995-06-01), Yen et al.
patent: 5474989 (1995-12-01), Hashimoto et al.
patent: 5658592 (1997-08-01), Tanihara et al.
patent: 5830459 (1998-11-01), Cuero et al.
patent: 6044800 (2000-04-01), Kubo et al.
patent: 6245901 (2001-06-01), Von der Osten et al.
patent: 6503847 (2003-01-01), Chen et al.
patent: 6562363 (2003-05-01), Mantelle et al.
patent: 6623950 (2003-09-01), Von der Osten et al.
patent: 6638621 (2003-10-01), Anderson et al.
patent: 6951632 (2005-10-01), Unger et al.
patent: 2002/0084194 (2002-07-01), Redepenning
patent: 2003/0170966 (2003-09-01), Lutz
patent: 2006/0078962 (2006-04-01), Chen et al.
patent: A 9 239 396 (1997-09-01), None
patent: 310041 (1998-11-01), None
patent: WO 00/11038 (2000-03-01), None
patent: WO 2004/018741 (2004-03-01), None
Sun et al., Tyronsinase-Containing Chitosan Gels: A Combined Catalysts and Sorbent for Selective Phenol Removal. Biotechnology and Bioengineering, vol. 51, pp. 79-86, (1996).
Tatsumi, K. et al., Removal of Phenols from Wastewater by an Enzyme and Chitosan, Advances in Chitin Sciences, vol. 2, pp. 864-869 (1997).
Muzzarelli, et al.,TYrosinase-Mediated Quinone Tanning of Chitinous Materials, Carbohydrate Polymers, vol. 24, pp. 295-300 (1994).
Wada et al., “Removal of Phenols and Aromatic Amines from Wastewater by a Combination . . . a Coagulent,” Biotechnology and Bioengineering, vol. 45, pp. 304-309 (1995).
Payne et al., “Tyrosinase Reaction/Chitosan Adsorption for Selectively Removing Phenols from Aqueous Mixtures,” Biotechnology & Bioengineering, 40, No. 9 (1992).
Seong, et al., “Fabrication of Microchambers Defined by Photopolymerized Hydrogels and Weirs . . . ,” Analytical Chemistry, vol. 74, No. 14, pp. 3372-3377 (2002).
Gao, et al., “Lateral Patterning of CDTe Nanocrystal Films by the Electric Field Directed Layer-by-Layer Assembly Method,” Langmuir, vol. 18, pp. 4098-4102 (2002).
Chen et al., “pH-Sensitive Thin Hydrogel Microfabricated by Photolithography,” Langmuir, vol. 14, pp. 6610-6612 (1998).
Beebe, et al., “Functional Hydrogel Structures for Autonomous Flow Control Inside Microfluidic Channels,” Nature, vol. 404, pp. 588-590 (2000).
Sirkar et al., “Amperometric Biosensors Based on Oxidoreductases Immobilized in Photopolymerized . . . ,” Analytic Chemistry, vol. 70, No. 14, pp. 2888-2984 (1998).
Li-Qun Wu, et al., “Chitosan-Mediated and Spatially Selective Electrodeposition of Nanoscale Particles,” Langmuir, vol. 21, No. 8, pp. 3641-3646 (2005).
Li-Qun Wu, et al., “Spatially Selective Deposition of a Reactive Polysaccharide Chitosan Layer onto a Patterned Template,” Langmuir, vol. 19, No. 3, pp. 519-524 (2003).
Li-Qun Wu, et al., “Voltage-Dependent Assembly of the Polysaccharide Chitosan onto an Electrode Surface,” Langmuir, vol. 18, No. 22, pp. 8620-8625 (2002).
Tianhong Chen, et al., “Enzymatic Methods for in Situ Cell Entrapment and Cell Release,” Biomacromolecules, vol. 4, No. 6, pp. 1558-1563 (2003).
Mark J. Kkastantin, et al., “Integrated Fabrication of Polymeric Devices for Biological Applications,” Invited Paper, Journal of Sensors and Materials, pp. 1-18 (Sep. 2003).
Tianhong Chen, et al., “Nature-Inspired Creation of Protein Polysaccharide Conjugate and Its Subsequent . . . Patterned Surface,” Langmuir, vol. 19, No. 22, pp. 9382-9386 (2003).
Rohan Fernandes, et al., “Electrochemical Induced Deposition of a Polysaccharide Hydrogel onto a Patterned Surface,” Langmuir vol. 19, No. 10, pp. 4058-4062 (2003).
Hyunmin, Yi, et al., “A Robust Technique for Assembly of Nucleic Acid Hybridization . . . Chitosan,” Analytical Chemistry, vol. 76, No. 2, pp. 365-372 (Jan. 15, 2004).
Rohan Fernandes, et al., “Thermo-Biolithography: A Technique for Patterning Nucleic Acids and Proteins,” Langmuir, vol. 20, No. 3, pp. 906-913 (2004).
Li-Qun Wu, et al., “Spatially Selective Asembly of a Reactive Polysaccharide Layer onto Patterned Surfaces,” Power Point Presentation of Nov. 8, 2002 (22 slides).
Takenaka, et al., “Sol-gel Preparation of a Single Layer, 0.75 Micron Thick Lead Zirconate Titanate Films . . . ,” Applied Physics Letters, vol. 79, No. 21, pp. 3485-3487 (2001).
O'Connor, et al., “Immobilization of Neural Cells in Three-Dimensional Matricesfor Biosensor Applications,” Biosensors & Bioelectrics, vol. 14, pp. 871-881 (2000).
Zhitomirsky, et al., “Cathodic Electrodeposition of Polymer Films and Organoceramic Films,” Material Science and Engineering, vol. B78, pp. 125-130 (2000).
Chen, et al., “Self-Assembly of Monolayers of Cadmium Selenide Nanocrystals with Dual Color Emission,” Langmuir, vol. 15, pp. 6845-6850 (1999).
Clark, “Engineering the Microfabrication of Layer-by-Layer Thin Films,” Advanced Materials (1998).
Gray, et al., “Interlocking Mechanical and Fluidic Interconnections for Microfluidic Circuit Boards”, Sensors and Actuators a-Physical, vol. 112, No. 1, pp. 18-24, 2004.
Li, et al., “Fabrication of Micronozzles Using Low-temperature Wafer-level Bonding with SU-8”,Journal of Micromechanics and Microengineering,vol. 13, No. 5, pp. 732-738, 2003.
Duffy, et al., “Rapid Prototyping of Microfluidic Systems in Poly (dimethylsiloxane).” Analytical Chemistry, vol. 70, No. 23, pp. 4974-4984, 1998.
Harrison, et al., “Capillary Electrophoresis and Sample Injection Systems Intergrated on a Planar Glass Chip”, Analytical Chemistry, vol. 64, No. 17, pp. 1926-1932, 1996.
Liang, et al., “Microfabrication of a Planar Absorbance and Fluorescence Cell for Integrated Capillary Electrophoresis Devices”, Analytical Chemistry, vol. 68, pp. 1040-1046,1996.
Voldman, et al., “An Integrated Liquid Mixer/Valve”, Journal of Microelectromechanical Systems, vol. 9, No. 3, pp. 295-302, 2001.
Glasgow, et al., “Handling Individual Mammalian Embryos Using Microfluidics”, IEEE Transactions on Biomedical Engineering, vol. 48, No. 5, pp. 570-577, 2001.
Fujii, et al., “PDMS-based Microfluidic Device for Biomedical Applications”, Microelectronic Engineering, vol. 61-62, pp. 907-914, 2002.
Yamaguchi, et al., “Rapid Fabrication of Electrochemical Enzyme Sensor Chip Using Polydimethylsiloxane Microfluidic Channel”, Analytica Chemica Acta,vol. 468, pp. 143-152, 2002.
Kim, et al., “A New Monolithic Microbiosensor for Whole Blood Analysis”, Sensors and Actuators, vol. A 95, pp. 108-113, 2002.
Trumbull, et al., “Integrating Microfabricated Fluidic Systems and NMR Spectroscopy”, IEEEE Transactions on Biomedical Engineering, vol. 47, No. 1, pp. 3-7, 2000.
Krishnan, et al., “Microfabricated Reaction and Separation Systems”, Curr. Opinion Biotech, vol. 12, pp. 92-98, 2001.
Hatch, et al., “A Ferrofluidic Magnetic Micropump”, Journal of Microelectromechanical Systems,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Fabrication and integration of polymeric bioMEMS does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fabrication and integration of polymeric bioMEMS, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fabrication and integration of polymeric bioMEMS will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3984904

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.